WT 104 H236 (disponible) - Monographie
Handbook of models for human aging / ed. CONN, P. Michael.
Amsterdam : Elsevier Academic Press, 2006, xxi, 1075 p.

Mots-clés principaux
Théorie biologique du vieillissement
Recherche sur le vieillissement
Expérimentation animale

Mots-clés secondaires : Andropause ; Apoptose ; Dépression ; Diabète ; Éthique de la recherche ; Fécondité ; Fragilité ; Hormone ; Hypertension artérielle ; Longévité ; Maladie d'Alzheimer ; Ménopause ; Neurobiologie ; Ostéoporose ; Recherche épidémiologique ; Santé ; Théorie des télomères ; Théorie génétique du vieillissement ; Théorie non génétique du vieillissement ; Trouble de la vision ; Trouble de l'audition

Résumé :

This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.

Table of contents :
I. Introduction
1. Historical Development of Animal Models of Aging
Richard L Sprott, Steven N Austad
2. Species Selection in Comparative Studies of Aging and Anti-Aging
Joao Pedro de Magalhaes
3. Principles of Animal Use for Gerontological Research
Richard A. Miller
4. From Primary Cultures to the Aging Organism: Lessons from Human T Lymphocytes
Rita B Effros
5. Models of Systems Failure in Aging
Leonid A Gavrilov, Natalia S. Gavrilova
6. Major Issues in Ethics of Aging Research
Michael D Smith
7. Ethical Aspects of Research Involving Elderly Persons
Paul S Mueller, C. Christopher Hook
II. General Methods
8. SAGE KE and Other Online Resources Related to Aging
Evelyn Strauss, R. John Davenport
9. Proteomics in Aging Research
Christian Schoneich
10. Application of High-throughput Technologies to Aging-related Research
Matt Kaeberlein
11. Models of Alzheimer's Disease
Harry LeVine, III, Lary C Walker
12. Age-Related Hippocampal Dysfunction: Early Alzheimer's Disease vs Normal Aging
Scott A Small
13. Epidemiology in Aging Research
Hermann Brenner, Volker Arndt
14. Statistical Issues for Longevity Studies in Animal Models
Chenxi Wang, Scott Keith, Kevin R Fontaine, David B Allison
15. Models for the Study of Infection in Populations
John R Williams
16. Estimation of the rate of production of oxygen radicals at mitochondria
Alberto Sanz, Gustavo Barja
III. Animal Models
A. Premammalian Systems
17. Telomeres and Aging in the Yeast Model System
Kurt W Runge
18. Longevity and Aging in the Budding Yeast
Matt Kaeberlein
19. From Yeast Methuselah Genes to Evolutionary Medicine
Paolo Fabrizio, Valter D. Longo
20. Strongyloides Ratti: A Nematode with Extraordinary Plasticity in Aging
Michael P. Gardner, David Gems, Mark Viney
21. Insect Models for the Study of Aging
Klaus-Guenter Collatz
22. Drosophila Models of Aging
Satomi Miwa, Alan Cohen
23. Models of Aging in Honeybee Workers
Gro V Amdam, Olav Rueppel
24. Ants as Naturally Long-lived Insect Models for Aging
Joel D Parker, Karen M Parker
B. Mammalian Systems
25. Gene Expression and the Extended Longevity Phenotypes of Drosophila melanogaster
Robert Arking
26. Annual Fish as a Genetic Model for Aging
Pudur Jagadeeswaran
27. The Use of Mature Zebrafish (Danio rerio) as a Model for Human Aging and Disease
Evan T Keller, Jill M. Keller, Gavin Gillespie
28. Zebrafish as Aging Models
Shuji Kishi
29. Telomeres In Aging: Birds
Susan E. Swanberg, Mary E. Delany
30. Domestic and Wild Bird Models for the Study of Aging
Donna J. Holmes, M.A. Ottinger
31. A Transgenic Mini Rat Strain as a Tool for Studying Aging and Calorie Restriction
Isao Shimokawa
32. Rat Models of Age-related Cognitive Decline
Jennifer L Bizon, Michelle M Nicolle
33. Aged Rodents for Biogerontology Research
Nancy L. Nadon
34. Life Extension in the Dwarf Mouse
Andrzej Bartke
35. The Canine Model of Human Brain Aging: Cognition, Behavior, and Neuropathology
P Dwight Tapp, Christina T Siwak
36. Bats as a Novel Model for Aging Research
Anja K Brunet-Rossinni, Rocco E. Rossinni
37. Memory in the Aging Hippocampus: What can place cells tell us?
Iain A Wilson
38. The Rhesus Macaque as a Model of Human Aging and Age-Related Disease
Mary Ann Ottinger, Jullie A. Mattison; Mary B. Zelinski, Julie M. Wu, Steve Kohama, George S. Roth, Mark A. Lane, Donald K. Ingram
39. Non-human Primates as a Model for Reproductinve Aging and Human Infertility
Barry D. Bavister, Carol A. Brenner
IV. Comparative Models
40. Neurobiology of the Aging Brain
Carlo Bertoni-Freddari, Patrizia Fattoretti, William Meier-Ruge
41. Mitochondrial DNA and Aging
Mikhail Alexeyev, Susan P. LeDoux, Glen L. Wilson
42. Models for Apoptosis
Christiane Charriaut-Marlangue, Sylvain Renolleau
43. Age-related Changes in Hormones and Their Receptors in Animal Models of Female Reproductive Senescence
Jacqueline A. Maffucci, Andrea C. Gore
44. Models of Chaperones in Aging
Jens Kroll, J. O. Nehlin
45. Therapeutic Potential of Stem Cells In Aging Related Diseases
Shannon Whirledge, Kirk C.L. Lo, and Dolores J. Lamb
46. Nuclear Transfer and Cloning: Preservaton or Expansion of Proliferative Lifespan?
Keith E Latham
47. Human Models of Longevity
Thomas Perls
48. Computational Models of Mitochondrial DNA in Aging
David C Samuels
49. Mouse Models of Accelerated Aging
Jan Vijg, Paul Hasty
V. Disease-States and Normal Aging
A. Disease States
50. Models, Definitions, and Criteria of Frailty
David B. Hogan
51. Fertility and Aging Men
Peter N Schlegel, Puneet Masson, Sarah M. Lambert, Harry Fisch
52. Benign Prostatic Hyperplasia
Peter N Celec
53. Murine Models of Infectious Diseases in the Aged
Kevin P High
54. Physiopathology, clinical symptoms and causative agents of pneumonia
Jean-Paul Janssens
55. Diabetes and Aging
Tamas Fulop, A. Larbi; D. Tessier, A. Carpentier
56. Diabetes as a Model of Premature Aging
Arshag D Mooradian
57. Frailty as a Model of Aging
Jeremy D. Walston
58. Osteoporosis and Cardiovascular Disease in the Elderly
Samy I McFarlane, MD, FACP, FACE, CCD, John Nicasio, Ranganath Muniyappa
59. Depression in Older Patients
Kiran Rabheru
60. The Aging Human Lung: Age-associated Changes in Structure and Function
Keith C. Meyer
61. Iceland as a Model for Human Aging
Adalsteinn Gudmundsson, Palmi V Jonsson
62. Behavior and Personality in the Study of Successful Aging
Judith Corr, Lorraine Tarou
B. Health Issues Affecting the Elderly
63. Andropause
Rabih Hijazi, Glenn R. Cunningham*
64. Aging and the perceptual organization of sounds: a change of scene?
Claude Alain, Benjamin J. Dyson, Joel S. Snyder
65. Models of Immune Function in Aging
Christopher A. Jolly, Zhun Xu
66. Human T Cell Clones in Long-term Culture as Models for the Impact of Chronic Antigenic Stress in Aging
Graham Pawelec, Erminia Mariani, Rafael Solana, Rosalyn Forsey, Anis Larbi, Simone Neri, Olga Dela Rosa, Yvonne Barnett, Jon Tolson, Tamas Fulop
67. Age-Related Changes in the Human Retina
Carlo Cavallotti, Nicola Pescosolido
68. Models of Age Related Vision Problems
J. Fielding Hejtmancik, Mark Kantorow, Takeshi Iwata
69. Health, Functional and Therapeutic Implications of Obesity in Aging
R L Kennedy, E Y H Khoo
70. Age and Joints
Klaus Bobacz, Ilse-Gerlinde Sunk
71. Sleep Quality in the Elderly
Ragnar Asplund
72. Atherogenesis and Aging
Cam Patterson
73. Managing Menopausal Symptons
Mary Ellen Rousseau
74. Psychological Aging: A Contextual View
Hans-Werner Wahl, Frieder R. Lang
75. Nutrients and Aging
Lawrence J Whalley
C. Approaches to Treatment and Models
76. Methods for Studying Hearing Impairment and Auditory Problems of the Aged
Robert D Frisina, D. Robert Frisina
77. A Model for Understanding the Pathomechanics of Osteoarthritis in Aging
Thomas P Andriacchi, Annegret Mundermann
78. Aging and Cardiovascular Angiogenesis Models
Andrew Chin, Jacquelyn M. Holm, Inga J. Duignan, and Jay M. Edelberg
79. Models for the Study of Stroke
Thiruma V. Arumugam, Mark P. Mattson
80. Werner Syndrome as a Model of Human Aging
Raymond J Monnat, Jr
81. Models of Sarcopenia
Alfred L Fisher
82. Aging of Human Skin
Paolo U Giacomoni
83. Models of Hypertension in Aging
Jane F Reckelhoff, Radu Iliescu, Licy Yanes, Lourdes A Fortepiani

Library of Congress Subject Headings for this publication:
Aging -- Handbooks, manuals, etc.
Models, Biological.
Models, Animal.

Illustrations : ill.
Langue : Anglais
Doc n° : 21875 ISBN / ISSN : 9780123693914
NumRec : 2187503


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