WM 219 B967m (disponible) - Monographie
Mild cognitive impairment and early Alzheimer's disease : detections and diagnosis / BURNS, Jeffrey M. ; MORRIS, John C..
Chichester, England : John Wiley & Sons, 2008, vii, 148 p.

Lieux géographiques
: Angleterre

Mots-clés principaux
Déficit cognitif léger
Maladie d'Alzheimer

Mots-clés secondaires : Diagnostic différentiel ; Diagnostic étiologique ; État de la recherche ; Neuropathologie ; Outil d'évaluation ; Outil de dépistage ; Traitement (Thérapeutique)

Résumé :

Written by leading authorities in the field, this book describes the cognitive changes associated with age, the earliest detectable stages of Alzheimer's, and the relationship of these conditions to MCI. The authors review the latest advances in our understanding of MCI, its prevalence, evaluation, management, and outcomes and in so doing provide practising physicians with a useful resource that assists them in identifying those MCI patients who will progress to recognised Alzheimer's Disease.

Beautifully presented in full colour, Early Diagnosis and Treatment of Mild Cognitive Impairment includes case studies and discusses future therapeutic and diagnostic strategies. It is an invaluable resource for postgraduates and professionals, for specialist physicians in neurology and psychiatric medicine, geriatric medicine and general practice.

Table des matières / Contents :

Chapter 1 Introduction
What is mild cognitive impairment?
Epidemiological studies of MCI
The border zone between aging and dementia: cognitive and neuropathological changes
Aging and cognitive performance

Chapter 2 Neuropathology of Alzheimer's disease, non-demented aging and MCI
Histopathological features
Neurofibrillary pathology
Neuronal loss
Topography of neuropathological changes
Neuropathological AD diagnosis
Neuropathology of aging
Neuropathology of MCI
Does a subset of MCI patients actually have early Alzheimer's disease?
Clinical studies

Chapter 3 Detecting and diagnosing MCI and early AD
Early detection
Recognition of MCI and early AD
Informant-based history
Neurological examination
Laboratory and radiological evaluation
Psychometric/mental status testing
Dementia-screening instruments
Mini-mental state examination
Clock-drawing test
Seven-minute screen
Dementia staging instruments
Global deterioration scale

Chapter 4 Etiology of MCI: differential diagnosis
Other etiologies
Neurodegenerative dementias
Overlap disorders
Dementia with Lewy bodies
Vascular dementia
Frontotemporal lobar dementias
Identifying the subset of MCI that is AD

Chapter 5 Treatment of MCI and dementia
The case for early treatment
Non-pharmacological treatment
Dementia therapy
Approved therapies
Cholinergic hypothesis
Cholinesterase inhibitors
Agents under investigation for AD treatment and prevention
Vitamin E and selegiline
Anti-inflammatory agents
Cholesterol-reducing agents
Chelation therapy

Chapter 6 Future therapeutic and diagnostic strategies
Amyloid hypothesis
Secretase inhibitors
Amyloid vaccine
Potential biomarkers
CSF biomarkers
CSF amyloid beta (Aß)
CSF tau
CSF sulfatide
CSF markers of inflammation
CSF markers of oxidative stress
Serum biomarkers
Structural imaging
Functional neuroimaging
Functional MRI (fMRI)
Imaging amyloid
Genetic testing
Early-onset familial AD
Amyloid precursor protein
Presenilin genes
Late-onset AD
Apolipoprotein E

7 Case studies
Case report 1: MCI as early-stage Alzheimer's disease
Case report 2: Diagnosis of dementia prior to impairment sufficient for MCI
Case report 3: Memory complaints associated with non-demented aging


Illustrations : graph. ; ill.
Langue : Anglais
Doc n° : 23760 ISBN / ISSN : 9780470319369
NumRec : 2376003


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