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Role of cognitive reserve in progression from mild cognitive impairment to dementia / ALLEGRI, Ricardo F. ; TARAGANO, Fernando E. ; KRUPITZKI, Hugo ; SERRANO, Cecilia M. ; DILLON, Carol ; SARASOLA, Diego ; FELDMAN, Monica ; TUFRO, Graciela ; MARTELLI, Maria ; SANCHEZ, Viviana.
Dementia & neuropsychologia, 2010, vol. 4 (1), p.28-34.

http://www.demneuropsy.com.br/imageBank/PDF/v4n1a05.pdf... (03-08-2010)
Droits d'auteur : Cette oeuvre est protégée par un droit d'auteur. Elle ne peut être reproduite qu'à des fins d'études privées ou de recherche et seulement si la source est mentionnée.

Lieux géographiques
: Brésil

Mots-clés principaux
:
Déficit cognitif léger
Facteur de risque
Démence
Fonction cognitive


Résumé :

Cognitive reserve is the ability to optimize performance through differential recruitment of brain networks, which may reflect the use of alternative cognitive strategies. Objectives: To identify factors related to cognitive reserve associated with progression from mild cognitive impairment (MCI) to degenerative dementia. Methods: A cohort of 239 subjects with MCI (age: 72.2±8.1 years, 58% women, education: 12 years) was assessed and followed for five years (2001 to 2006). Results: In the first year, 13.7% of MCI converted to dementia and 34.7% converted within three years (78.3% converted to Alzheimer's dementia). Risk factors for those who converted were education less than 12 years, MMSE score less than 27, Boston naming test score less than 51, IQ (Intelligence Quotient) less than 111, age over 75 years, lack of occupation at retirement, and presence of intrusions in memory recall (all account for 56% of the variability of conversion). Conclusions: MCI patients are a population at high risk for dementia. The study of risk factors (e.g. IQ, education and occupation), particularly those related to cognitive reserve, can contribute important evidence to guide the decision-making process in routine clinical activity and public health policy.

Illustrations : tableaux
Langue : Anglais
Doc n° : 27121
NumRec : 5526803
 

       

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