Article

(disponible) - Article
Efficacy and safety of brand-risperidone versus similar-risperidone in elderly patients with neuropsychiatric disorders : a retrospective study / CUNHA FOLQUITTO, Jefferson ; BARBOSA DE BARROS, Sérgio ; ARRAIS PINTO JUNIOR, Jony ; BOTTINO, Cassio M. C..
Dementia & neuropsychologia, 2010, vol. 4 (1), p.69-74.

http://www.demneuropsy.com.br/imageBank/PDF/v4n1a12.pdf... (03-08-2010)
Droits d'auteur : Cette oeuvre est protégée par un droit d'auteur. Elle ne peut être reproduite qu'à des fins d'études privées ou de recherche et seulement si la source est mentionnée.

Lieux géographiques : Brésil

Mots-clés principaux :
Tranquilisant
placebo
Neuropsychiatrie
Trouble cognitif
Effet secondaire


Résumé :
To compare the efficacy and tolerability of brand-risperidone against similar-risperidone in elderly outpatients. Method: The medical files of 16 elderly outpatients from the IPq-HCFMUSP treated with two formulations of risperidone (brand and similar) between July/1999 and February/2000 were reviewed. Two independent raters, using the Clinical Global Impression scale, evaluated the efficacy of the treatment with risperidone and the frequency of adverse effects. Results: Comparing October/1999 to November/1999, Rater 1 observed a trend (p=0.059) and Rater 2 found a statistically significant difference, in favor of the brand-risperidone group (p=0.014). Comparing October/1999 to February/2000, Rater 1 observed no statistically significant difference (p=0.190), but the Rater 2 found a statistically significant difference in favor of the brand-risperidone group (p=0.029). Comparing November/1999 to February/2000, both raters found no statistically significant differences between both risperidone formulations. Regarding adverse effects, a statistically significant difference (p=0.046) was found in favor of the patients treated with brand-risperidone. Conclusions: The risperidone-reference, compared to similar-risperidone, showed a trend toward greater efficacy and tolerability.

Illustrations : tableaux ; graph.
Langue : Anglais

Doc n° : 27129
NumRec : 5531303